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UPDATE
Given new evidence on the B.1.617.2 (Delta) variant, CDC has updated the guidance for fully vaccinated people. CDC recommends universal indoor masking for all teachers, staff, students, and visitors to K-12 schools, regardless of vaccination status. Children should return to full-time in-person learning in the fall with layered prevention strategies in place.

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The White House announced that vaccines will be required for international travelers coming into the United States, with an effective date of November 8, 2021. For purposes of entry into the United States, vaccines accepted will include FDA approved or authorized and WHO Emergency Use Listing vaccines. More information is available here.

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Travel requirements to enter the United States are changing, starting November 8, 2021. More information is available here.

Safety of COVID-19 VaccinesSafety of COVID-19 Vaccines

Updated June 13, 2022

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What You Need to Know
COVID-19 vaccines are safe and effective.
Millions of people in the United States have received COVID-19 vaccines under the most intense safety monitoring in US history.
CDC recommends you get a COVID-19 vaccine as soon as possible.

Hundreds of Millions of People Have Safely Received a COVID-19 Vaccine

More than 591 million doses of COVID-19 vaccine had been given in the United States from December 14, 2020, through June 13, 2022. To view the current total number of COVID-19 vaccinations that have been administered in the United States, please visit the CDC COVID Data Tracker.
COVID-19 vaccines are safe and effective. COVID-19 vaccines were evaluated in tens of thousands of participants in clinical trials. The vaccines met the Food and Drug Administration’s (FDA’s) rigorous scientific standards for safety, effectiveness, and manufacturing quality needed to support emergency use authorization (EUA). Learn more about EUAs in this video.
The Pfizer-BioNTech, Moderna, and Johnson & Johnson/Janssen COVID-19 vaccines will continue to undergo the most intensive safety monitoring in US history. This monitoring includes using both established and new safety monitoring systems to make sure that COVID-19 vaccines are safe.
Common Side Effects
Some people have side effects after getting their COVID-19 vaccine, while others might have no side effects. Side effects may affect the ability to do daily activities, but they should go away within a few days. Learn more about common side effects after COVID-19 vaccination.
Serious Safety Problems Are Rare
In rare cases, people have experienced serious health events after COVID-19 vaccination. Any health problem that happens after vaccination is considered an adverse event. An adverse event can be caused by the vaccine or can be caused by a coincidental event not related to the vaccine, such as an unrelated fever, that happened following vaccination.
To date, the systems in place to monitor the safety of these vaccines have found four serious types of adverse events following COVID-19 vaccination, with evidence that suggests, although rare, a link to certain types of COVID-19 vaccinations that were administered. They are:
Anaphylaxis
Anaphylaxis is a severe type of allergic reaction with symptoms such as hives, difficulty breathing, low blood pressure, or significant swelling of the tongue or lips. Anaphylaxis after COVID-19 vaccination is rare. Learn more about COVID-19 vaccines and allergic reactions, including anaphylaxis.
Thrombosis with Thrombocytopenia Syndrome (TTS)
Thrombosis with thrombocytopenia syndrome (TTS) is a rare but serious adverse event that causes blood clots or issues with clotting. TTS after COVID-19 vaccination is rare. Learn more about COVID-19 vaccines and adverse events, including TTS.
Myocarditis and Pericarditis
Myocarditis is inflammation of the heart muscle, and pericarditis is inflammation of the outer lining of the heart. Myocarditis and pericarditis after COVID-19 vaccination are rare. Learn more about COVID-19 vaccines and adverse events, including myocarditis and pericarditis.
Guillain-Barré Syndrome (GBS)
Guillain-Barré Syndrome (GBS) is a rare disorder where the body’s immune system damages nerve cells, causing muscle weakness and sometimes paralysis. GBS after COVID-19 vaccination is rare. Learn more about COVID-19 vaccines and adverse events, including GBS.
Reports of Death Are Rare
Reports of death after COVID-19 vaccination are rare. FDA requires healthcare providers to report any death after COVID-19 vaccination to the Vaccine Adverse Event Reporting System (VAERS), even if it’s unclear whether the vaccine was the cause. Reports of adverse events to VAERS following vaccination, including deaths, do not necessarily mean that a vaccine caused a health problem. CDC and FDA review reports of death following COVID-19 vaccination and update information as it becomes available. Learn more about adverse events, including reports of death, after COVID-19 vaccination.
Benefits of Vaccination Outweigh the Risks
Serious side effects that could cause a long-term health problem are extremely unusual following any vaccination, including COVID-19 vaccination. The benefits of COVID-19 vaccination outweigh the known and potential risks.
CDC continues to closely monitor the safety of COVID-19 vaccines. Everyone who receives a COVID-19 vaccine can also participate in safety monitoring by enrolling themselves, their children ages five years and older, or other dependents in a smartphone-based system called v-safe and completing health check-ins after COVID-19 vaccination.
Have you experienced a side effect following COVID-19 vaccination?
Please report it to VAERS. In addition, enrolling yourself or your dependent in v-safe allows you to easily report to CDC how you are feeling after getting a COVID-19 vaccine.

More Information
ACIP COVID-19 Vaccines Safety Technical Sub-Group (VaST)
COVID-19 Vaccine Safety Publications
VaST Subgroup Technical Report
v-safe After Vaccination Health Checker
Vaccine Adverse Event Reporting System (VAERS)

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Last Updated June 13, 2022 Content source: National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases

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